NIPER-R
NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH
Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India

Dr. Ranjan graduated from University of Delhi, Delhi (India) where he received both B.Sc.(Hons.) and M.Sc. (Organic Chemistry) degrees majoring in Chemistry. He then went overseas to earn his Ph.D degree in Chemistry from Clemson University in South Carolina (United States) in 2012. After his post-doctoral training at NUBAD, LLC,in Greenville (United States) he returned back to India to join TERI-DEAKIN Nanobiotechnology Research Center at Gurgaon (India) in March 2016. He joined the faculty at NIPER-Raebareli in November 2017 where his research focuses on development of small molecule- nucleic acid binders of therapeutic interest.

  1. Verma S, Ravichandiran, V., Ranjan N, and Flora S.J.S. Recent Advances in Therapeutic Applications of Bisbenzimidazoles, Medicinal Chemistry, 2019, 15, 1-31. Web Link

  2. Ranjan N., Arya Dev P. A fluorescent aminosugar to rapidly screen and study RNA binders. Methods in Enzymology 2019, 623, 291-314. Web Link

  3. Smita Verma, Sandip A. Ghuge, V. Ravichandiran, Ranjan N*. Spectroscopic studies of Thioflavin-T binding to c-Myc G-quadruplex DNA. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 212, 388-395. Web Link

  4. Story, Sandra, Michael J. Skriba, Krishnagopal Maiti, Nihar Ranjan, Natalya N. Degtyareva, Keith D. Green, Verjine Khodaverdian, Adegboyega K. Oyelere, Sylvie Garneau-Tsodikova, and Dev P. Arya. "Synthesis, antimicrobial activity, attenuation of aminoglycoside resistance in MRSA, and ribosomal A-site binding of pyrene-neomycin conjugates." European Journal of Medicinal Chemistry 2018.

  5. Sayantan Bhaduri, Ranjan N* and Dev P. Arya. "An overview of recent advances in duplex DNA recognition by small molecules."Beilstein Journal of Organic Chemistry, (2018) Vol 14, Pages 1051-1086.

  6. Thamban Chandrika, Nishad, Sanjib K. Shrestha, Nihar Ranjan, Anindra Sharma, Dev P. Arya, and Sylvie Garneau-Tsodikova. "New Application of Neomycin B–Bisbenzimidazole Hybrids as Antifungal Agents." (2018) ACS infectious diseases, 4 (2), pp 196–207. Web Link

  7. Ranjan, N., Kellish, P., King, A., & Arya, D. P. Impact of Linker Length and Composition on Fragment Binding and Cell Permeation: Story of a Bisbenzimidazole Dye Fragment.  (2017) Biochemistry, 56(49),6434-6447.  Web Link

  8. Deshmukh Sunil K*, Prakash V. and Ranjan N*.  Marine Fungi: A Source of Potential Anticancer compounds 8 (2017) Frontiers in Microbiology (DOI: 10.3389/fmicb.2017.02536) *as corresponding author Web Link

  9. Ranjan N.,Fulcrand F,Ahmed M., King A.,  Sur S., Leng F., Yuk-Ching Tse-Dinh  and Arya D. P.    Selective inhibition of Escherichia coli DNA and RNA topoisomerase  by Hoechst 33258 derived Mono and Bisbenzimidazoles (2017) J. Med. Chem. 60 (12) 4904-4922. Web Link

  10. Deshmukh Sunil K*, Prakash V. and Ranjan N*.  Recent advances in the discovery of bioactive metabolites from Pestalotiopsis  (2017) Phytochemistry Reviews 1-38 (DOI: 10.1007/s11101-017-9495-3) * as corresponding author Web Link

  11. Ranjan Nihar*, Kumar Umesh, Deshmukh Sunil K*.    Novel targets and advancements in drug discovery: the case of HIV-AIDS; book chapter in Bioresources and Bioprocesses in Technology (Volume II), Springer publications (2017). * as corresponding author (Chapter 18, pages 419-438) Web Link

  12. Ranjan N.; Arya Dev P.  Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in  RNA vs. DNA binding Bioorg. Med. Chem. Lett (2016) 26 (24) 5989-5994 Web Link)

  13. Kumar S., Ranjan N., Kellish Patrick C., Arya Dev P. Multivalency in Recognition and Antagonism of HIV TAR RNA-TAT assembly using an aminoglycoside –Benzimidazole scaffold, Org Biomol Chem. (2016) 14 (6) 2052-2056 Web Link

  14. Nahar S., Ranjan N., Arya Dev P., Maiti S.  Potent inhibition of miR-27a by neomycin-bisbenzimidazole conjugates (2015) Chemical Science  (2015)  6 (10), 5837-5846 Web Link

  15. Woo, C.M., Ranjan, N., Arya, D.P., Herzon, S. B. Analysis of Diazofluorene DNA binding and damaging activity: DNA cleavage by a synthetic monomeric diazofluorene. Angew Chem Int Ed (2014) 53, 9325-9328; Web Link

  16. Ranjan, N., Fulcrand, G., King, A., Brown, J., Xiang, X., Leng, F., Arya, D. P. Selective inhibition of bacterial topoisomerase I by alkynyl-bisbenzimidazoles. (2014) Med ChemComm, 5, 816-825; Web Link

  17. Ranjan, N., Davis, E., Xue, L., and Arya, D. P. Dual recognition of the human telomeric G-quadruplex by a neomycin-anthraquinone conjugate.  (2013) Chem. Comm.49, 5796-5798; Web Link

  18. Ranjan, N., Kumar, S., Watkins, D., Wang, D., Appella, D. H., and Arya, D. P. Recognition of HIV-TAR RNA using neomycin–benzimidazole conjugates.(2013) Bioorg. Med. Chem. Lett., 23, 5689-5693. Web Link

  19. Ranjan N.; Arya, D.P. Targeting C-myc G-quadruplex: Dual recognition by aminosugar-bisbenzimidazoleswih varying linker lengths. (2013) Molecules, 18, 14228-14240; Web Link

  20. Watkins, D., Ranjan, N., Kumar, S., Gong, C., and Arya, D. P. An assay for human telomeric G-quadruplex DNA binding drugs.(2013) Bioorg. Med. Chem. Lett., 23(24), 6695-6699; Web Link.

  21. King, A., Watkins, D., Kumar, S., Ranjan, N., Gong, C., Whitlock, J., and Arya, D. P. Characterization of ribosomal binding and antibacterial activities using two orthogonal high throughput capable screens. (2013) Antimicrob. Agents Chemotherapy, 57(10) 4717-4726;Web Link

  22. Xi, H., Davis, E., Ranjan, N., Xue, L., Hyde-Volpe, D., and Arya, D. P. Thermodynamics of Nucleic Acid "Shape Readout" by an Aminosugar.(2011) Biochemistry. 50, 9088-9113; Web Link

  23. Xue, L., Ranjan, N., and Arya, D. P. Synthesis and Spectroscopic Studies of the Aminoglycoside (Neomycin)-Perylene Conjugate Binding to Human Telomeric DNA. (2011) Biochemistry. 50, 2838-2849; Web Link.

  24. Ranjan, N., Andreasen, K. F., Kumar, S., Hyde-Volpe, D., and Arya, D. P. Aminoglycoside Binding to Oxytricha NovaTelomeric DNA.  (2010) Biochemistry. 49, 9891-9903; Web Link

Research:

Dr. Ranjan’s research involves developing new ligands that target nucleic acids of different types with specificity and high affinity. This includes synthesis of small molecules that recognize bacterial RNA sequences of therapeutic interest; particularly towards the discovery of new anti-tuberculosis agents. His other area of interest is development new fluorescent molecules that sense and stabilize G-quadruplex structures in the human genome.

Patents:

 

  1. Selective Inhibition of Bacterial Topoisomerase I. Ranjan N.,Arya Dev P. and Leng F., 2015, US Patent No.  9,920,014
  2. Methods and Compositions of Triazolyl Oligosaccharides Related to Viral Inhibition Arya Dev P., Ranjan N., and   Kumar S, 2011,  US Patent No.    9492554

 

Extramural Grants:

  1. DST-SERB Core Research Grant ( Start Year- 2019)
  2. DBT- Foldscope (Indo-US) Bilateral Grant (Start Year 2018)